![]() ![]() UV radiation causes direct and indirect DNA damage. Researchers believe that there are two main pathways of pathogenesis in BCC: UV radiation-induced carcinogenesis and genetic mutations. White individuals over age 65 have the highest incidence of BCC. Increasing age (associated with increased cumulative sun exposure).Organ transplant recipients receiving immunosuppressive drugs and individuals with immunosuppressive diseases are at an elevated risk of developing skin cancers, particularly SCC. Family history or personal history of BCC, squamous cell carcinoma (SCC), actinic keratosis, familial dysplastic nevus syndrome, or atypical nevi.Individuals with a light complexion (fair skin that freckles and burns easily), light-colored eyes (blue, green, or other light-colored eyes), and light-colored hair (red or blond) who have had substantial exposure to sunlight. People who have had sunburns are predisposed to the development of BCC. Skin cancers are more common in the southern latitudes of the Northern hemisphere. Epidemiological evidence suggests that cumulative exposure to UV radiation and the sensitivity of an individual's skin to UV radiation are risk factors for skin cancer. Sun and ultraviolet (UV) radiation exposure (including tanning beds).Risk factors for nonmelanoma skin cancer include: Men have had a higher rate than women, although this difference is becoming less significant with changes in lifestyles, such as tanning beds and smoking. It rarely occurs on the mucous membranes or on the palms and soles. ![]() The incidence of BCC is increasing worldwide at an annual rate of close to 10%.īCC is rarely fatal, but it can cause significant local destruction, disfigurement, and morbidity if not recognized or adequately treated.īCC occurs most commonly on sun-damaged skin of the head, neck, trunk, and extremities. It is estimated to affect close to one in five Americans. BCC is the more common type, accounting for about three-quarters of nonmelanoma skin cancers. Nonmelanoma skin cancer is the most common cancer in the U.S. She underwent Mohs surgery to remove the lesions, and O'Connell reported that "all cancerous tissue was successfully removed and the margins were clear of any residual cancer cells." Biden's lesions were found during a routine skin cancer screening. In January, First Lady Jill Biden, EdD, also was diagnosed with two BCCs: One was under her right eye and the other on the left side of her chest. He will, however, undergo continued dermatological surveillance. The lesion had been detected as part of his "comprehensive health assessment." The lesion was biopsied and then "treated presumptively with electrodessication and curettage (EDC) at the time of the biopsy." All the cancerous tissue was successfully removed, the wound is healing well, and no further treatment is necessary for the president. White House physician Kevin O'Connor, DO, is now reporting that the biopsy results of the lesion confirmed that the growth was a basal cell carcinoma (BCC). Last month, President Biden had a skin lesion removed from his chest.
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